February 2020 - The lab has moved to DFCI!

We are very excited to be unpacking boxes in our second new home at the Dana-Farber. Come visit us in Mayer 633/634.

January 2020 - Tothova lab welcomes Florence Verbeek

We are thrilled to welcome Florence Verbeek as a visiting graduate student from the University of Amsterdam, Netherlands. Florence is currently pursuing a medical degree as well as a masters degree in Biomedical Sciences. She has previously studied drug resistance in gastrointestinal malignancies. Her work in the lab will focus on therapeutic targeting of cohesin-mutant MDS and AML. Outside of the lab, she is an avid CrossFitter, and enjoys reading and watching reruns of The Office. ​

December 2019 - Secret Santa

Our annual tradition. A few gifts remained to be found at the reveal party.

December 2019 - ASH annual meeting

Mounica Vallurupalli presented the first oral presentation of the Tothova lab at the 2019 annual meeting of the American Society of Hematology in Orlando, FL. She discussed the development of new mouse models of cohesin-mutant myeloid disease and the preclinical studies with the PARP inhibitor talazoparib leading to a Phase 1b clinical trial of talazoparib in cohesin-mutant MDS/AML patients.

November 2019 - Tothova lab welcomes Han Lin

We are very excited to welcome Han Lin, PhD, a new postdoctoral fellow in the lab. Han Lin is joining our lab from the Cancer Science Institute of Singapore/National University of Singapore where she recently completed her PhD in Dr. Phil Koeffler’s lab. Her doctoral work was focused on understanding the function of ARID1A, a component of the SWI/SNF chromatin remodeling complex, in normal hematopoietic development. Welcome, Han Lin!

September 2019 - Jimmy Fund Walk

The Tothova Lab and Friends participated in our second Jimmy Fund Walk on a beautiful first day of fall. This year, we walked the full marathon course and were still smiling at the finish line! Thank you to all of our supporters.

September 2019 - Tothova lab welcomes Karin Golan

We are thrilled to welcome Karin Golan, PhD, a new postdoctoral fellow in the lab. Karin is joining our lab from the Weizmann Institute where she did her PhD with Tsvee Lapidot studying different aspects of basic hematopoietic stem cell biology, including the influence of light and darkness, mitochondrial transfer with bone marrow environment and the role of sphingosine 1-phosphate in HSC motility. Welcome, Karin!

August 2019 - Farewell to our summer student  Ben Maron

We are sad to see our fantastic summer student Ben Maron leave us to start his junior year at Williams College. He has had an incredibly productive summer in the lab and we are eager to welcome him back to the lab in a few months!

​July 2019 - Tothova Lab is awarded the Doris Duke Clinical Scientist Development Award

We are very grateful to the Doris Duke Charitable Foundation for supporting our work on splicing in cohesin-mutant MDS/AML

July 2019 - Tothova Lab welcomes Liana Tellez

Today, we welcomed Liana Tellez as the newest member of the lab. Liana is joining us from Northwestern University as a research associate in the Broad Genomics Scholar program.

July 2019 - Tothova Lab turns 1!

Today we celebrated the first year anniversary of our lab, celebrated friendships and collaborations, and welcomed a new addition to our team, Liana Tellez.

June 2019 - Mounica's send off to the Brigham for her chief medical residency year

We will miss Mounica as she embarks on her year as a chief medical resident at the Brigham and Women's Hospital.

June 2019 - Tothova lab is awarded the Discovery Research grant from the Evans Foundation

We are very grateful to the EvansMDS initiative of the Evans Foundation to support our work on targeting DNA damage repair in cohesin-mutant MDS

June 2019 - Tothova lab is awarded the inaugural RUNX1 Young Investigator Award

We are very grateful for the support from the RUNX1 Research program and Alex's Lemonade Stand for our study of disease progression in familial platelet disorders to MDS and AML

May 2019 - Tothova lab welcomes Ben Maron

Today, we welcome Ben Maron to our lab. Ben is a rising junior at Williams College majoring in biology and mathematics, and a recipient of the Williams-Whitehead fellowship for the summer. He will be working on understanding the effect of cohesin complex mutations on nascent transcription.

April 2019 - Zuzana Tothova receives the Tito Bastianello Award

We are very grateful to the MDS Foundation for recognizing our work on mechanisms of cohesin mutations in myelodysplastic syndromes during the 15th International Symposium on Myelodysplastic syndromes in Copenhagen, Denmark.

April 2019 - Celebrating our first PDX model!

March 2019 - Ski trip

Our winter getaway to Cranmore Mountain, NH.

Birthday celebrations 2018-2019

Aaaand... we are one year older!
December 2018 - Tothova Lab Holiday Party
Our first annual holiday party marked by the first Christmas tree ornament.
December 2018 - Secret Santa
The annual Secret Santa tradition dating back to the Gilliland lab era continues.
​December 2018 - ASH annual meeting
We attended the annual meeting of the American Society of Hematology in San Diego. 
October 2018 - B.A.A. Half Marathon
Congratulations to all the runners for conquering the Boston half marathon on this beautiful fall day!
September 2018 - The Jimmy Fund Walk
The Tothova lab and friends team participated in the Jimmy Fund Walk celebrating its 30th anniversary on a beautiful first day of fall. We joined thousands of patients, families and care givers to walk 13.1 mile half marathon route from Wellesley to Boylston Street.

August 2018 - Farewell to Anastasia

Today, we said goodbye to our fabulous summer student, Anastasia Tishena. She will be missed most for her mastery of the CellTiter-Glo assay as well as her wit in lab. Anastasia leaves us to start her junior year at Williams College. Click below to see some more photos of Anastasia's summer in the Tothova Lab. 

August 2018 - Sailing in the Charles River

The Tothova and Ebert lab spent this beautiful summer evening sailing in the Charles River. Click below to see some more photos!

July 2018 - Farewell to Kiki

To celebrate Kiki's last day in the Tothova and Ebert labs, we all set off to the Arboretum for a picnic! Kiki leaves the lab after two years. She is now off pursuing a Masters of Nutrition Science & Policy at Tufts University. We are all sad to see her go, but happy to know she'll be in Boston for the time being! Click below to see some photos from her farewell picnic. 

July 1, 2018 - Tothova Lab welcomes Anastasia Tishena 

Today, we also welcomed Anastasia to the Tothova Lab. Anastasia will be joining the lab for the next 10 weeks working on drug synergy experiments in various leukemia cell lines. Anastasia is joining us from Williams College, where she just finished up her sophomore year as a biology major and biochemistry concentrator. 

July 1, 2018 - Tothova Lab welcomes Rebecca Gorelov 

Today, Rebecca joined the Tothova Lab as a research associate. Rebecca just graduated from Williams College as a biology major. She joins the lab to help develop different model systems to study leukemia.  

July 1, 2018 - Tothova Lab welcomes Mounica Vallurupalli 

On its opening day, the Tothova Lab welcomes its first postdoc, Mounica Vallurupalli. She joins us from Dana Farber, where she is a clinical fellow in hematology-oncology. In the lab she will be studying the role of epigenetic alterations, including in the cohesin complex, in the development of leukemia as well as in mediating response and resistance to therapy.

July 1, 2018 - Tothova Lab Opens!

July 1st marks the opening of the Tothova Lab. We are excited to open our lab at the Broad Institute, studying the epigenetic changes that contribute to various myeloid malignancies.