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October 2023 - Happy Halloween from our family to yours!Can you find you favorite antibody?
Evon: MHCI - BV421, Caroline: hCD45-PE-Cy7, Serena: PE-Dazzle, Molly: Cas9-AF488, Ben: gH2Ax-FITC, Han Lin: lineage cocktail-PE-Cy7, Elodie: cohesin-V5 sitting on an R loop, Johann: cKit-APC, Veronica: H3K27Ac-APC, Zuzana: CD34-BV421. |
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October 2023 - Dr. Tothova receives the Paragon Award from the Doris Duke FoundationDr. Tothova was presented The Paragon Award for research excellence during a ceremony in New York City celebrating 25 years of Doris Duke Foundation (DDF) support of physician-scientists . The Paragon Award for Research Excellence is a one-time recognition of physician-scientists who have “significantly advanced knowledge toward the prevention, diagnosis and treatment of human disease or who have, through their professional contributions, improved health outcomes of patients today.” (photo credit: Dom McGee, productionglue)
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October 2023 - Welcome to Veronica!We are very excited to welcome Veronica Hsu, a first year PhD student in the HMS Immunology Program as a rotation student in our lab. Before starting graduate school, Veronica was a technician in Dr. Jianzhu Chen's lab at MIT developing next-generation natural killer cell immunotherapeutics. She is very excited to learn more about the role of the immune system in progression of blood diseases. Outside of the lab, Veronica enjoys water sports, exploring the greater Boston area, and crocheting.
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October 2023 - Welcome to Molly!We are thrilled to welcome Molly Moore, a first year PhD student in the BBS program as a rotation student in our lab! Prior to starting graduate school, Molly was a Research Associate in the lab of Dr. Fadi Najm at the Broad Institute, where she worked on developing and applying CRISPR-based technologies to characterize how regulatory elements shape gene expression. Molly completed her bachelor’s degree in Biology and English at Bowdoin College, where she studied 3D genome organization in fruit flies in Dr. Jack Bateman's lab. Outside of the lab, Molly enjoys churning homemade ice cream, spending time outdoors, making ceramic mugs, and reading speculative fiction.
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October 2023 - Congratulations to Amy and Johann!Many congratulations to Amy and Johann for being awarded Abstract achievement awards for their annual ASH meeting abstracts! Looking forward to their presentations in San Diego in December.
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September 2023 - Welcome to Serena Landini!We are very excited to welcome Serena Landini as the lab research operations manager. Serena is originally from Italy and graduated with a masters degree in Medicinal Chemistry and Pharmacognosy from The Ohio State University. Before joining our lab, Serena worked as a principal research technician In David Livingston's lab In the Department of Cancer Biology at the DFCI for 15 years and contributed to multiple projects involving BRCA1and its role in DNA damage repair. Outside of the lab, she spends most of her time with her son and friends, and she enjoys cooking, art and traveling around Europe and the United States.
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September 2023 - Welcome to Elodie Hatchi!Very warm welcome to Elodie Hatchi, a senior staff scientist joining our team. Elodie received her bachelor and master’s degrees in Biochemistry, completed her PhD at the Institute of Molecular Genetics of Montpellier, France, and did her postdoc in David Livingston's lab at DFCI where she worked on new avenues of BRCA1-mediated DNA damage repair and explored the role of RNA in genomic integrity maintenance. Outside of the lab, she’s an artist/musician who also enjoys the outdoors, exercising, cooking, and quality time with family and friends.
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July 2023 - Welcome to Evon!We are absolutely thrilled to have Evon Wang joining the team as a research associate. Evon recently graduated from Tufts University with a double major in Biology and Community Health. At Tufts, Evon worked at the Molecular Cardiology Research Institute with Dr. Iris Jaffe to investigate the vascular side effects that arise from the targeted tyrosine kinase inhibitors used to treat CML. Outside of the lab, Evon loves dancing ballet and contemporary, reading nonfiction books and finding good ice cream shops.
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July 2023 - Welcome back to Caroline!We are extremely excited to welcome Caroline back to the lab as a research associate. Caroline recently defended her undergraduate thesis at Harvard in our lab and is going to spend the next couple of years in the lab before pursuing her dream to become a physician scientist.
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July 2023 - Welcome to Kate!Very warm welcome to Kate Drachman who is joining the lab as a summer student. Kate is a junior at The Winsor School and is from Newton, Massachusetts. She is excited to join the Tothova lab and contribute to cancer research. Outside of the lab, Kate enjoys playing squash, baking, and walking her dog.
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July 2023 - Welcome to Rick!We are thrilled to welcome Rick to our lab this summer. Rick is a first year MD-PhD student in the Harvard-MIT HST program. He graduated from Harvard College in 2021 with an A.B. in Human Developmental and Regenerative Biology and worked as a Research Assistant in Dr. Vijay Sankaran’s lab at Boston Children’s Hospital and the Broad Institute characterizing regulators of fetal-to-adult hemoglobin switching. He is excited to pursue questions related to cancer biology and human development over the coming years.
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May 2023 - Gordon conference on cancer epigeneticsWe got to experience a perfect combination of amazing science and beautiful Tuscan rolling hills and vineyards at the Gordon conference on genetics and cancer epigenetics. The only thing that made it even better was the company, reconnecting with old friends, and new friendships and collaborations made!
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May 2023 - Amy wins the ASH Honors Award!Congratulations to Amy for being selected for the ASH Honors Award! We are absolutely thrilled to have her back with us in the lab this summer.
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April 2023 - Johann is awarded the LLS Scholar award!Many congratulations to Johann who was selected as one of the Leukemia and Lymphoma Society Scholar awardees. So well deserved!
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February 2023 - Welcome to Keely!We welcome Keely Ji, our new rotation student in the lab! Keely is a first year Ph.D. student in the Harvard Immunology Program. She graduated from UC Davis in 2022 with a B.S. in Cell Biology. At UC Davis, she was an undergraduate researcher in Dr. Chang-il Hwang’s lab, investigating epigenetic therapies that could induce synthetic lethality with DNA repair deficiencies in familial pancreatic cancer. She is interested in understanding epigenetics in immune cells and human disease.
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December 2022 - Congratulations to Han Lin!Congratulations to Han Lin for being selected as a 2022 Helen Gurney Brown Fellow !
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September 2022 - Our degron profiling paper is out!Exciting to see the fruits of this truly amazing team effort on testing 5 different degron strategies across multiple targets, including our very own cohesin subunits, out in print. Congratulations to Dylan and the rest of the team.
You can read it here. |
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July 2022 - Welcome to Ben!We are super excited about Ben Braun joining our team as a new computational research associate! Ben is originally from Germany. He graduated from Clemson University with a Bachelor of Computer Science and minors in Biology and Genetics. At Clemson, Ben worked with Dr. Pingshan Wang on applied machine learning and signal processing for microfluidic sensor systems. When he isn't working, Ben enjoys mountain biking, coding, and good books, preferably with good coffee.
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July 2022 - Our berry picking/beach summer outing!It was a perfect July weekend to head up north to Ipswich for some seriously delicious blueberry and raspberry picking at Russell Orchards, followed by a picnic on the Crane estate and beach time on Crane beach. And did we mention ice-cream? Yeah, we snuck that in too. What a fun way to celebrate the summer with the Burns lab!
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June 2022 - Tothova Lab is awarded a grant from the Edward P. Evans MDS Foundation!We are extremely grateful for the continued support of the Edward P. Evans MDS foundation! Our new 3-year long grant will help support our studies elucidating the role of inflammation during development of cohesin-mutant MDS.
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June 2022 - Welcome back to Sofia!We are so excited to have Sofia back with us in the lab! Sofia recently graduated from Williams College with a degree in in Biology and a concentration in Spanish, where she also completed her honors thesis in Dr. Lois Banta's lab, investigating the impact of the Type VI secretion system in Agrobacterium tumefaciens on defensive signaling in A. thaliana. Outside the lab, she enjoys singing, reading, and hiking.
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June 2022 - Welcome to Caroline!We are thrilled welcome Caroline as the newest addition to our team. Caroline comes to us from Wesleyan University where she recently graduated with dual degrees in Biology and French studies, and a minor in informatics and modeling. At Wesleyan, Caroline did her undergraduate research in Joe Coolon's lab investigating gene regulation and dietary specialization in Drosophila. Caroline is originally from Seattle, and enjoys hiking, reading, and visiting as many coffee shops as possible.
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March 2022 - Our ski trip turned winter hiking tripWe did not let the unseasonably warm temperatures and rain get in the way of our winter ski getaway to New Hampshire. We succeeded in staying upright and not breaking any bones as we braved a climb to a water fall and a lake, followed by a visit to a Bavarian chocolate haus where even our very own German found something authentic! And who knew that people could get so competitive playing Blockus and Pictionary...
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March 2022 - Caroline wins the Herchel Smith Fellowship!Congratulations to Caroline for being awarded the Herchel Smith Undergraduate Science Research fellowship! So well deserved!
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February 2022 - Our paper identifying cohesin and CTCF as suppressors of PD-L1 is out!Congratulations to Emily for leading a collaboration with the Elledge lab that led to the identification of cohesin and CTCF proteins as negative regulators of PD-L1, interferon and NF-kB signaling.
You can read it here! |
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February 2022 - Congratulations to Han Lin!Congratulations to Han Lin for being selected as a Helen Gurney Brown Fellow!
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December 2021 - Secret SantaHappy holidays from our family to yours!
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December 2021 - ASH 2021It was great to be back at ASH, hear about great science and reconnect with friends.
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October 2021 - Congrats to Johann for receiving a grant from the German Research Foundation!Congratulations to Johann for being awarded a grant from the German Research Foundation (The Deutsche Forschungsgemeinschaft, DFG) to support his work on cohesin-mutant MDS!
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August 2021 - we welcome Johann JannWe are absolutely thrilled to welcome Johann to our team. He is coming to us from University of Heidelberg in Germany where he completed his MD in Daniel Nowak’s lab, studying the clonal dynamics in MDS. While completing his clinical training in internal medicine at the University Medical Center Mannheim, Germany, he developed both wet lab and bioinformatics skills for genome-wide mutational and transcriptional analysis to support clinical decision making for patients with MDS and AML. In the Tothova lab he is interested in studying how cohesin mutations confer competitive advantage to stem cells leading to the clonal dominance and in ways to tackle them therapeutically. Outside the lab, Johann’s two toddlers keep him busy, he is a passionate cyclist and looks forward to resuming his activity as a semi-professional singer after the pandemic.
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June 2021 - Our cohesin review is published!You can read it here!
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June 2021 - Tothova Lab welcomes Sofia NeaherWe are very excited to welcome Sofia Neaher as a Williams-Whitehead scholar to our lab this summer. Sofia is a rising senior at Williams College where she is majoring in Biology, alongside a concentration in Spanish. She has previously worked in Dr. Paul Campbell’s laboratory at the Fox Chase Cancer Center, focusing on the interactions of the mutant K-Ras and HuR proteins in pancreatic ductal adenocarcinoma. She is also pursuing a thesis in Dr. Lois Banta’s lab, investigating the impact of the Type VI secretion system in Agrobacterium tumefaciens on defensive signaling in A. thaliana. Outside the lab, she enjoys singing, reading, and hiking.
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June 2021 - Tothova Lab welcomes Caroline ConwayWe are thrilled to have Caroline Conway join our lab. Caroline is a junior at Harvard College studying Chemical and Physical Biology with a secondary in History. She previously worked in Dr. Cliff Tabin’s laboratory, where she utilized mouse models to investigate the relationship between variants of EDAR and mammary gland density. Outside of the lab, Caroline enjoys reading, knitting, and dancing with the Harvard Ballet Company and Harvard Radcliffe Modern Dance Company.
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April 2021 - Remembering Francisco MartyWe mourn the loss of Francisco Marty, a brilliant physician, clinical investigator and teacher, and one of the kindest and most generous human beings on this planet. He was a wonderful friend of the lab and shared his gift of photography with us, capturing the most important events in the lab with his special lens. We will miss his infectious smile, his love of selfies and passion for medicine and life. May he rest in peace.
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March 2021 - Tothova Lab welcomes Sana ShareefWe are very excited to have Sana Shareef join our lab. Sana is a junior at Harvard College where she studies Human, Developmental and Regenerative Biology with a secondary major in Religion. She has previously studied the effect of Prostaglandin E2 (PGE2) on hematopoietic and melanocyte stem cell function in Jonathan Hoggatt's laboratory where she also helped develop targeted leukemia therapy models involving gene-edited hematopoietic stem cells. Outside of the lab, she enjoys reading, learning Urdu poetry, and staying active with yoga, pilates and dance.
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March 2021 - Celebrating Emily's F32 grant success!
Congratulations to Emily on hitting a home run with her F32 application!
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February 2021 - Our cohesin paper is published!You can read it here!
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December 2020 - Florence wins the best student thesis prize!Congratulations to Florence for winning the best student thesis prize from the The Nijbakker-Morra Foundation!
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November 2020 - Karin wins the Helen Gurley Brown fellowship!
Congratulations to Karin on being selected as one of the 2020 Helen Gurley Brown Fellows!
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September 2020 - Tothova Lab Welcomes Margaret ZimmerWe are very happy to welcome Margaret Zimmer as a rotating graduate student in our lab. Margaret is a second-year Harvard BBS PhD student whose general scientific interests include cancer biology, immunology, and genetics. Outside of the lab, she is a proud dog mom of an Australian cattle dog mix named Ace and an avid sports fan.
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September 2020 - Tothova Lab Welcomes Amy WangWe are very excited to have Amy Wang join our lab as a new computational research associate. Originally from Seattle, she graduated from Brown University in 2020, where she majored in computational biology and completed an undergraduate thesis involving a comparative analysis of various genetic fusion detection programs. Amy hopes to assist the lab in their studies of the epigenetic underpinnings of myeloid malignancies. Outside of the lab, she enjoys reading, drawing, and the occasional jog.
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September 2020 - Tothova Lab welcomes Emily WheelerWe are thrilled to welcome Emily as a new postdoc in our lab. Emily completed her PhD in Gene Yeo's lab at UC San Diego studying the role of cancer-associated point mutations in splicing factor proteins on RNA recognition and alternative splicing. Additionally, she developed a technology (CRaft-ID) utilizing microraft arrays with high-throughput imaging to perform a CRISPR-screen for regulators of cytoplasmic protein-RNA assemblies in cells. As a graduate student, Emily was trained in both wet and dry lab techniques to develop a hybrid skill set between bioinformatics and bench work in the lab. In the Tothova lab, she is interested in studying the cross-talk between RNA splicing and cohesin function in various cell line and animal models of MDS and AML. Outside the lab, Emily loves to stay active with soccer (pre-pandemic times), rock climbing, cycling, and skiing.
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August 2020 - The Tothova Lab joins the Ludwig Center at Harvard Medical SchoolWe are thrilled and honored to be joining the community of the Ludwig Center at Harvard Medical School and are grateful for the support of our work focused on modeling and therapeutic targeting of myeloid diseases
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June 2020 - Farewell to BeccaWe wish all the best to Becca Gorelov who is leaving the lab after two wonderful years to start her PhD in the Biological and Biomedical Sciences Program at Harvard Medical School this summer. We celebrated her time and many important scientific contributions in the lab with a socially distanced picnic. We are very sad to see her go but thrilled that she will be staying in Boston!
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June 2020 - Tothova Lab welcomes Dylan MillsonWe are very happy to welcome Dylan Millson who is joining our team as a new research associate. Dylan grew up in North Carolina and graduated from Williams College in 2020 with degrees in chemistry and biology. He was a four-year member of Williams wrestling team. Dylan completed his undergraduate thesis in the lab of Prof. Ben Thuronyi, where he developed a modular DNA toolkit to enable fluorescent proteins to form phase condensates in E. coli. In the Tothova lab, he aims to study genetic and epigenetic aberrations that contribute to myeloid malignancies. When he isn't in the lab, Dylan enjoys reading, lifting weights, and playing electric bass.
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March 2020 - Tothova Lab welcomes Will DoyleWe are very excited to welcome Will Doyle as a new research associate in the Tothova lab. Will grew up in Arlington, MA and graduated from Williams College in 2019 with a major in biology. For his undergraduate thesis in the lab of Prof. Lois Banta, he studied the connected roles of a plant defense hormone and the bacterial type VI secretion system in Agrobacterium tumefaciens infection. Will is joining the Tothova Lab to contribute to the understanding of epigenetic dysregulation in leukemia development. Outside of the lab, he enjoys playing jazz trombone, studying languages, and baking bread.
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February 2020 - The lab has moved to DFCI!We are very excited to be unpacking boxes in our second new home at the Dana-Farber. Come visit us in Mayer 633/634.
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January 2020 - Tothova lab welcomes Florence VerbeekWe are thrilled to welcome Florence Verbeek as a visiting graduate student from the University of Amsterdam, Netherlands. Florence is currently pursuing a medical degree as well as a masters degree in Biomedical Sciences. She has previously studied drug resistance in gastrointestinal malignancies. Her work in the lab will focus on therapeutic targeting of cohesin-mutant MDS and AML. Outside of the lab, she is an avid CrossFitter, and enjoys reading and watching reruns of The Office.
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December 2019 - ASH annual meetingMounica Vallurupalli presented the first oral presentation of the Tothova lab at the 2019 annual meeting of the American Society of Hematology in Orlando, FL. She discussed the development of new mouse models of cohesin-mutant myeloid disease and the preclinical studies with the PARP inhibitor talazoparib leading to a Phase 1b clinical trial of talazoparib in cohesin-mutant MDS/AML patients.
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November 2019 - Tothova lab welcomes Han LinWe are very excited to welcome Han Lin, PhD, a new postdoctoral fellow in the lab. Han Lin is joining our lab from the Cancer Science Institute of Singapore/National University of Singapore where she recently completed her PhD in Dr. Phil Koeffler’s lab. Her doctoral work was focused on understanding the function of ARID1A, a component of the SWI/SNF chromatin remodeling complex, in normal hematopoietic development. Welcome, Han Lin!
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September 2019 - Tothova lab welcomes Karin GolanWe are thrilled to welcome Karin Golan, PhD, a new postdoctoral fellow in the lab. Karin is joining our lab from the Weizmann Institute where she did her PhD with Tsvee Lapidot studying different aspects of basic hematopoietic stem cell biology, including the influence of light and darkness, mitochondrial transfer with bone marrow environment and the role of sphingosine 1-phosphate in HSC motility. Welcome, Karin!
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May 2019 - Tothova lab welcomes Ben MaronToday, we welcome Ben Maron to our lab. Ben is a rising junior at Williams College majoring in biology and mathematics, and a recipient of the Williams-Whitehead fellowship for the summer. He will be working on understanding the effect of cohesin complex mutations on nascent transcription.
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September 2018 - The Jimmy Fund Walk
The Tothova lab and friends team participated in the Jimmy Fund Walk celebrating its 30th anniversary on a beautiful first day of fall. We joined thousands of patients, families and care givers to walk 13.1 mile half marathon route from Wellesley to Boylston Street.
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August 2018 - Farewell to AnastasiaToday, we said goodbye to our fabulous summer student, Anastasia Tishena. She will be missed most for her mastery of the CellTiter-Glo assay as well as her wit in lab. Anastasia leaves us to start her junior year at Williams College. Click below to see some more photos of Anastasia's summer in the Tothova Lab.
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July 2018 - Farewell to KikiTo celebrate Kiki's last day in the Tothova and Ebert labs, we all set off to the Arboretum for a picnic! Kiki leaves the lab after two years. She is now off pursuing a Masters of Nutrition Science & Policy at Tufts University. We are all sad to see her go, but happy to know she'll be in Boston for the time being! Click below to see some photos from her farewell picnic.
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July 1, 2018 - Tothova Lab welcomes Anastasia TishenaToday, we also welcomed Anastasia to the Tothova Lab. Anastasia will be joining the lab for the next 10 weeks working on drug synergy experiments in various leukemia cell lines. Anastasia is joining us from Williams College, where she just finished up her sophomore year as a biology major and biochemistry concentrator.
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July 1, 2018 - Tothova Lab welcomes Mounica VallurupalliOn its opening day, the Tothova Lab welcomes our very first clinical fellow, Mounica Vallurupalli. She joins us from Dana Farber, where she is a clinical fellow in hematology-oncology. In the lab she will be studying the role of epigenetic alterations, including in the cohesin complex, in the development of leukemia as well as in mediating response and resistance to therapy.
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July 1, 2018 - Tothova Lab Opens!July 1st marks the opening of the Tothova Lab. We are excited to open our lab at the Broad Institute, studying the epigenetic changes that contribute to various myeloid malignancies.
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