October 2024 - Jimmy Fund WalkThe weather could not have been more perfect for our half marathon walk from Wellesley to Boston Commons. Conquering cancer one step at a time! Thanks to all who supported our walk!
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September 2024 - Welcome to Charlotte!Warm welcome to Charlotte Cools, the newest member of our lab, who is joining us from Belgium as a Belgian American Educational Foundation Fellow. Charlotte is a medical student at KU Leuven who will spend a year doing research in our lab. Outside of the lab, she enjoys staying active through running and fitness. Music is also a big part of her life, and she loves playing guitar and singing.
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August 2024 - Sailing on the Charles!It could not have been a more beautiful Boston summer evening on the Charles to celebrate the end of the summer!
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August 2024 - Welcome to Ariel!We are thrilled to welcome Ariel Swett to our lab! Ariel is an MD/PhD student in her first year of the Chemical Biology PhD program at Harvard. She graduated from Johns Hopkins with a B.S. in Molecular and Cellular Biology and Spanish. While in college, she studied yeast telomere length regulation in the Greider Lab. After graduating, Ariel worked as a research technician in the Landau Lab at Weill Cornell Medicine. There, she developed novel wet lab methods to expand the modes of data collected in single-cell and spatial transcriptomics experiments and implemented them to study liquid and solid tumors. Ariel is excited to expand her chemical biology toolkit and apply it to the study of cohesin and chromatin.
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July 2024 - Our paper identifying distinct biology and outcomes of cohesin mutations in AML is out!Congratulations to Johann, Ben and the rest of our team and collaborators on a nice story identifying distinct ontogeny and outcomes in subunit-specific analysis of cohesin-mutant myeloid malignancies. Find the link to the published paper in Leukemia here!
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July 2024 - Farewell to Ben and CarolineWe wish all the best to Caroline and Ben who are leaving the lab after a couple wonderful years to start graduate school. Their contributions to our lab's mission and culture will echo for many years to come. We will miss them dearly and can't wait to see all the amazing things they will accomplish.
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June 2024 - Welcome to Nkazi!We are thrilled to welcome Nkazi Nchinda as a rotation student. Nkazi is a second year MD-PhD student in the Harvard-MIT HST program. He grew up outside Milwaukee, WI and graduated from Harvard College in 2021 with an A.B. in Biomedical Engineering. Following graduation, he studied Global Health Science and Epidemiology at the University of Oxford, researching the evolution of new HIV strains in UNAIDS key populations. After an additional year studying Public Policy, he's excited to be back in Boston studying how cancer cells evolve and which selective pressures guide this evolution. Outside of the lab, you’ll find him baking new recipes or exploring new photography spots in Boston.
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June 2024 - Becca defends her PhD!Many congratulations to our very own Becca Gorelov, the founding member of the Tothova lab, who successfully defended her PhD in Biology from Harvard Medical School in Dr. Konrad Hochedlinger's lab! We could not be more proud and happy for her, especially since she found a way back to her love of hematopoiesis and stem cells!
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June 2024 - European Association of Hematology meetingWe enjoyed great science and perfect weather in the beautiful Madrid. Johann continued his TRTH program while Zuzana presented in a special working group session on stem cells.
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June 2024 - Welcome to Rishika!Warm welcome to Rishika Vadlamudi who joins our lab as an associate computational biologist. Rishika recently graduated from Johns Hopkins University with dual Bachelor’s and Master's degrees in Biomedical Engineering and a secondary Bachelor's degree in Computer Science. At Johns Hopkins, Rishika worked on various computational biology projects including a predictive model for perioperative hemodynamic risk under Dr. Joseph Walpole and Dr. Joseph Greenstein. Outside of work, Rishika enjoys painting, attending live music shows and exploring Boston.
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May 2024 - Congratulations to our graduates!Many congratulations to Ben and Caroline on their acceptances to graduate school! Ben will be pursuing a PhD in computational biology at University of Colorado Boulder and Caroline will be starting her PhD in Biology in the BBS program at Harvard in the fall. So very proud and excited to see these stars take off in the world!
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May 2024 - Welcome to Kate!We are excited to welcome a new undergraduate student to our lab! Kate is a rising sophomore at Harvard College planning to study chemistry or biology. She is excited to join the Tothova Lab and contribute to understanding the role of chromatin in blood cancers. Outside of school, Kate enjoys reading and playing classical viola in the Harvard-Radcliffe Orchestra.
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February 2024 - Congratulations to Johann for being selected for the TRTH program!Many congratulations to Johann for being inducted into the prestigious Translational Research Training program in Hematology (TRTH) Hall of Fame! TRTH is a year-long training and mentoring program organized by the European Hematology Association (EHA) and the American Society of Hematology (ASH) and is focused on helping early-career scientists build successful careers in hematological translational research. So proud!
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February 2024 - Dr. Tothova is awarded the basic/translational research junior faculty ASH Scholar awardWe are extremely grateful to the American Society of Hematology for supporting our work!
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January 2024 - Our Science Translational Medicine paper is out!Many congratulations to Emily and Ben, and the rest of our team and collaborators on getting our work on mechanisms of splicing modulation in cohesin-mutant myeloid malignancies published in STM! This was a wonderful collaboration with Karen's Adelman lab at HMS. What a great way to start the new year!
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December 2023 - Secret Santa revealHappy holidays and best wishes for the new year from our family to yours!
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December 2023 - Amy and Johann rock it at ASH!Congratulations to Amy and Johann for doing a stellar job presenting their work at ASH and both receiving ASH abstract achievement awards!
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December 2023 - Gingerbread house floor competitionCongratulations to the team for winning 1st place in our floor gingerbread house competition. It was an amazing team effort and the final product too beautiful to eat.
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October 2023 - Welcome to Joelle!We are excited to welcome Joelle Williams to our team. Joelle is a sophomore at Harvard College studying Human Developmental and Regenerative Biology. She is very interested in medicine, as well as Spanish and music. She’d love to study abroad one day and I enjoys playing classical piano.
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October 2023 - Happy Halloween from our family to yours!Can you find you favorite antibody?
Evon: MHCI - BV421, Caroline: hCD45-PE-Cy7, Serena: PE-Dazzle, Molly: Cas9-AF488, Ben: gH2Ax-FITC, Han Lin: lineage cocktail-PE-Cy7, Elodie: cohesin-V5 sitting on an R loop, Johann: cKit-APC, Veronica: H3K27Ac-APC, Zuzana: CD34-BV421. |
October 2023 - Dr. Tothova receives the Paragon Award from the Doris Duke FoundationDr. Tothova was presented The Paragon Award for research excellence during a ceremony in New York City celebrating 25 years of Doris Duke Foundation (DDF) support of physician-scientists . The Paragon Award for Research Excellence is a one-time recognition of physician-scientists who have “significantly advanced knowledge toward the prevention, diagnosis and treatment of human disease or who have, through their professional contributions, improved health outcomes of patients today.” (photo credit: Dom McGee, productionglue)
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October 2023 - Welcome to Veronica!We are very excited to welcome Veronica Hsu, a first year PhD student in the HMS Immunology Program as a rotation student in our lab. Before starting graduate school, Veronica was a technician in Dr. Jianzhu Chen's lab at MIT developing next-generation natural killer cell immunotherapeutics. She is very excited to learn more about the role of the immune system in progression of blood diseases. Outside of the lab, Veronica enjoys water sports, exploring the greater Boston area, and crocheting.
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October 2023 - Welcome to Molly!We are thrilled to welcome Molly Moore, a first year PhD student in the BBS program as a rotation student in our lab! Prior to starting graduate school, Molly was a Research Associate in the lab of Dr. Fadi Najm at the Broad Institute, where she worked on developing and applying CRISPR-based technologies to characterize how regulatory elements shape gene expression. Molly completed her bachelor’s degree in Biology and English at Bowdoin College, where she studied 3D genome organization in fruit flies in Dr. Jack Bateman's lab. Outside of the lab, Molly enjoys churning homemade ice cream, spending time outdoors, making ceramic mugs, and reading speculative fiction.
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October 2023 - Jimmy Fund Walk!It could not have been a more perfect Sunday morning to start the 13.1 mile course from Wellesley to Fenway along the Boston marathon route in support of the Dana-Farber and all the work done in our lab. Conquering cancer one step at a time!
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September 2023 - Welcome to Serena Landini!We are very excited to welcome Serena Landini as the lab research operations manager. Serena is originally from Italy and graduated with a masters degree in Medicinal Chemistry and Pharmacognosy from The Ohio State University. Before joining our lab, Serena worked as a principal research technician In David Livingston's lab In the Department of Cancer Biology at the DFCI for 15 years and contributed to multiple projects involving BRCA1and its role in DNA damage repair. Outside of the lab, she spends most of her time with her son and friends, and she enjoys cooking, art and traveling around Europe and the United States.
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September 2023 - Welcome to Elodie Hatchi!Very warm welcome to Elodie Hatchi, a senior staff scientist joining our team. Elodie received her bachelor and master’s degrees in Biochemistry, completed her PhD at the Institute of Molecular Genetics of Montpellier, France, and did her postdoc in David Livingston's lab at DFCI where she worked on new avenues of BRCA1-mediated DNA damage repair and explored the role of RNA in genomic integrity maintenance. Outside of the lab, she’s an artist/musician who also enjoys the outdoors, exercising, cooking, and quality time with family and friends.
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August 2023 - Tothova Lab is awarded a grant from the Gabrielle's Angel Foundation!We are very grateful to the Gabrielle's Angel Foundation on supporting our work on inflammation during STAG2-mutant MDS initiation and progression!
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August 2023 - FASEB on Hematologic MalignanciesCongratulations to Han Lin on doing an excellent job presenting our work on R loops in cohesin-mutant myeloid malignancies!
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July 2023 - Sailing on the Charles!It's been five years and the lab has grown but sailing on the Charles on a beautiful summer evening is still the same - marvelous! Thank you to our captain Mikolaj and his many apprentices for steering our sail boat. See more photos below!
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July 2023 - Welcome to Evon!We are absolutely thrilled to have Evon Wang joining the team as a research associate. Evon recently graduated from Tufts University with a double major in Biology and Community Health. At Tufts, Evon worked at the Molecular Cardiology Research Institute with Dr. Iris Jaffe to investigate the vascular side effects that arise from the targeted tyrosine kinase inhibitors used to treat CML. Outside of the lab, Evon loves dancing ballet and contemporary, reading nonfiction books and finding good ice cream shops.
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July 2023 - Welcome back to Caroline!We are extremely excited to welcome Caroline back to the lab as a research associate. Caroline recently defended her undergraduate thesis at Harvard in our lab and is going to spend the next couple of years in the lab before pursuing her dream to become a physician scientist.
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July 2023 - Welcome to Kate!Very warm welcome to Kate Drachman who is joining the lab as a summer student. Kate is a junior at The Winsor School and is from Newton, Massachusetts. She is excited to join the Tothova lab and contribute to cancer research. Outside of the lab, Kate enjoys playing squash, baking, and walking her dog.
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July 2023 - Welcome to Rick!We are thrilled to welcome Rick to our lab this summer. Rick is a first year MD-PhD student in the Harvard-MIT HST program. He graduated from Harvard College in 2021 with an A.B. in Human Developmental and Regenerative Biology and worked as a Research Assistant in Dr. Vijay Sankaran’s lab at Boston Children’s Hospital and the Broad Institute characterizing regulators of fetal-to-adult hemoglobin switching. He is excited to pursue questions related to cancer biology and human development over the coming years.
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June 2023 - Tothova Lab receives continued support from the Ludwig center at HMSWe are extremely honored and grateful to receive continued support of our work on modeling and therapeutic targeting of myeloid malignancies from the Ludwig Center at HMS for the next three years.
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May 2023 - Gordon conference on cancer epigeneticsWe got to experience a perfect combination of amazing science and beautiful Tuscan rolling hills and vineyards at the Gordon conference on genetics and cancer epigenetics. The only thing that made it even better was the company, reconnecting with old friends, and new friendships and collaborations made!
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May 2023 - Caroline defends her thesis!Congratulations to Caroline on completing an absolutely superb honors thesis. We are so excited and proud of you and can't wait to see all the amazing things you will do.
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February 2023 - Dr. Tothova becomes a Break Through Cancer InvestigatorDr. Tothova and her lab have joined the Break Through Cancer Targeting clonal hematopoiesis to prevent AML team.
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February 2023 - Welcome to Keely!We welcome Keely Ji, our new rotation student in the lab! Keely is a first year Ph.D. student in the Harvard Immunology Program. She graduated from UC Davis in 2022 with a B.S. in Cell Biology. At UC Davis, she was an undergraduate researcher in Dr. Chang-il Hwang’s lab, investigating epigenetic therapies that could induce synthetic lethality with DNA repair deficiencies in familial pancreatic cancer. She is interested in understanding epigenetics in immune cells and human disease.
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December 2022 - Secret Santa revealWarmest wishes for the new year!
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December 2022 - Back at ASH!Congratulations to Emily for her excellent presentation of her work on mechanisms of splicing modulation in cohesin-mutant MDS and AML!
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November 2022 - Cancer program retreat in StoweIt was so fun to reconnect with new and old friends and colleagues, and welcome the first snow in beautiful Stowe, VT!
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November 2022 - Happy Halloween! |
October 2022 - Dr. Tothova receives the Helen Trailblazer awardWe are extremely grateful to the Helen Gurley Brown Foundation for supporting Dr. Tothova and her lab in their work elucidating the basic mechanisms of cohesin mutations during MDS and AML development.
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September 2022 - Our degron profiling paper is out!Exciting to see the fruits of this truly amazing team effort on testing 5 different degron strategies across multiple targets, including our very own cohesin subunits, out in print. Congratulations to Dylan and the rest of the team.
You can read it here. |
July 2022 - Farewell to Amy and WillWe wish all the best to Amy and Will who are leaving the lab after a couple wonderful years and moving on to medical school and graduate school. We will miss them dearly and can't wait to see all the amazing things they will accomplish.
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July 2022 - Welcome to Ben!We are super excited about Ben Braun joining our team as a new computational research associate! Ben is originally from Germany. He graduated from Clemson University with a Bachelor of Computer Science and minors in Biology and Genetics. At Clemson, Ben worked with Dr. Pingshan Wang on applied machine learning and signal processing for microfluidic sensor systems. When he isn't working, Ben enjoys mountain biking, coding, and good books, preferably with good coffee.
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July 2022 - Our berry picking/beach summer outing!It was a perfect July weekend to head up north to Ipswich for some seriously delicious blueberry and raspberry picking at Russell Orchards, followed by a picnic on the Crane estate and beach time on Crane beach. And did we mention ice-cream? Yeah, we snuck that in too. What a fun way to celebrate the summer with the Burns lab!
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June 2022 - Tothova Lab is awarded a grant from the Edward P. Evans MDS Foundation!We are extremely grateful for the continued support of the Edward P. Evans MDS foundation! Our new 3-year long grant will help support our studies elucidating the role of inflammation during development of cohesin-mutant MDS.
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June 2022 - Welcome back to Sofia!We are so excited to have Sofia back with us in the lab! Sofia recently graduated from Williams College with a degree in in Biology and a concentration in Spanish, where she also completed her honors thesis in Dr. Lois Banta's lab, investigating the impact of the Type VI secretion system in Agrobacterium tumefaciens on defensive signaling in A. thaliana. Outside the lab, she enjoys singing, reading, and hiking.
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June 2022 - Welcome to Caroline!We are thrilled welcome Caroline as the newest addition to our team. Caroline comes to us from Wesleyan University where she recently graduated with dual degrees in Biology and French studies, and a minor in informatics and modeling. At Wesleyan, Caroline did her undergraduate research in Joe Coolon's lab investigating gene regulation and dietary specialization in Drosophila. Caroline is originally from Seattle, and enjoys hiking, reading, and visiting as many coffee shops as possible.
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May 2022- Congratulations to Amy and Will!Many congrats to Amy and Will, our youngest generation of Tothova Lab graduates heading to graduate school and medical school! We are so very proud of all your accomplishments and can't wait to see where your new adventures take you!
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March 2022 - Our ski trip turned winter hiking tripWe did not let the unseasonably warm temperatures and rain get in the way of our winter ski getaway to New Hampshire. We succeeded in staying upright and not breaking any bones as we braved a climb to a water fall and a lake, followed by a visit to a Bavarian chocolate haus where even our very own German found something authentic! And who knew that people could get so competitive playing Blockus and Pictionary...
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February 2022 - Our paper identifying cohesin and CTCF as suppressors of PD-L1 is out!Congratulations to Emily for leading a collaboration with the Elledge lab that led to the identification of cohesin and CTCF proteins as negative regulators of PD-L1, interferon and NF-kB signaling.
You can read it here! |
January 2022 - Farewell to KarinWe bid farewell to Karin who is starting as a principal scientist at Surface Oncology. Congratulations and best wishes!
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October 2021 - Happy Halloween!Impersonation of our favorite chromatin complex loaded on DNA for Halloween 2021!
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October 2021 - Florence receives the best student thesis prizeCongratulations to Florence Verbeek, a former masters thesis student in our lab, who received the best student thesis prize from the Nijbakker-Morra Foundation in Amsterdam, the Netherlands.
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August 2021 - we welcome Johann JannWe are absolutely thrilled to welcome Johann to our team. He is coming to us from University of Heidelberg in Germany where he completed his MD in Daniel Nowak’s lab, studying the clonal dynamics in MDS. While completing his clinical training in internal medicine at the University Medical Center Mannheim, Germany, he developed both wet lab and bioinformatics skills for genome-wide mutational and transcriptional analysis to support clinical decision making for patients with MDS and AML. In the Tothova lab he is interested in studying how cohesin mutations confer competitive advantage to stem cells leading to the clonal dominance and in ways to tackle them therapeutically. Outside the lab, Johann’s two toddlers keep him busy, he is a passionate cyclist and looks forward to resuming his activity as a semi-professional singer after the pandemic.
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August 2021 - Tothova Lab summer outing!Celebrating summer at Boston Harbor Islands, welcoming Johann and bidding farewell to Dylan and our summer students.
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August 2021 - celebrating our summer students!Lots to celebrate this summer with our two wonderful summer students, including many summer birthdays!
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July 2021 - We turned 3!Today we celebrated our 3rd birthday. This experiment has been a great fun! Here's to everyone who helped make the last three years so successful! And we are looking forward to many more successes and celebrations in the future.
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June 2021 - Our cohesin review is published!You can read it here!
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June 2021 - Tothova Lab welcomes Sofia NeaherWe are very excited to welcome Sofia Neaher as a Williams-Whitehead scholar to our lab this summer. Sofia is a rising senior at Williams College where she is majoring in Biology, alongside a concentration in Spanish. She has previously worked in Dr. Paul Campbell’s laboratory at the Fox Chase Cancer Center, focusing on the interactions of the mutant K-Ras and HuR proteins in pancreatic ductal adenocarcinoma. She is also pursuing a thesis in Dr. Lois Banta’s lab, investigating the impact of the Type VI secretion system in Agrobacterium tumefaciens on defensive signaling in A. thaliana. Outside the lab, she enjoys singing, reading, and hiking.
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June 2021 - Tothova Lab welcomes Caroline ConwayWe are thrilled to have Caroline Conway join our lab. Caroline is a junior at Harvard College studying Chemical and Physical Biology with a secondary in History. She previously worked in Dr. Cliff Tabin’s laboratory, where she utilized mouse models to investigate the relationship between variants of EDAR and mammary gland density. Outside of the lab, Caroline enjoys reading, knitting, and dancing with the Harvard Ballet Company and Harvard Radcliffe Modern Dance Company.
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April 2021 - Remembering Francisco MartyWe mourn the loss of Francisco Marty, a brilliant physician, clinical investigator and teacher, and one of the kindest and most generous human beings on this planet. He was a wonderful friend of the lab and shared his gift of photography with us, capturing the most important events in the lab with his special lens. We will miss his infectious smile, his love of selfies and passion for medicine and life. May he rest in peace.
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March 2021 - Tothova Lab welcomes Sana ShareefWe are very excited to have Sana Shareef join our lab. Sana is a junior at Harvard College where she studies Human, Developmental and Regenerative Biology with a secondary major in Religion. She has previously studied the effect of Prostaglandin E2 (PGE2) on hematopoietic and melanocyte stem cell function in Jonathan Hoggatt's laboratory where she also helped develop targeted leukemia therapy models involving gene-edited hematopoietic stem cells. Outside of the lab, she enjoys reading, learning Urdu poetry, and staying active with yoga, pilates and dance.
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February 2021 - Our cohesin paper is published!You can read it here!
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Birthday celebrations 2020-2021Aaaaand..... we are another year older!
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September 2020 - Tothova Lab Welcomes Margaret ZimmerWe are very happy to welcome Margaret Zimmer as a rotating graduate student in our lab. Margaret is a second-year Harvard BBS PhD student whose general scientific interests include cancer biology, immunology, and genetics. Outside of the lab, she is a proud dog mom of an Australian cattle dog mix named Ace and an avid sports fan.
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September 2020 - Tothova Lab Welcomes Amy WangWe are very excited to have Amy Wang join our lab as a new computational research associate. Originally from Seattle, she graduated from Brown University in 2020, where she majored in computational biology and completed an undergraduate thesis involving a comparative analysis of various genetic fusion detection programs. Amy hopes to assist the lab in their studies of the epigenetic underpinnings of myeloid malignancies. Outside of the lab, she enjoys reading, drawing, and the occasional jog.
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September 2020 - Tothova Lab welcomes Emily WheelerWe are thrilled to welcome Emily as a new postdoc in our lab. Emily completed her PhD in Gene Yeo's lab at UC San Diego studying the role of cancer-associated point mutations in splicing factor proteins on RNA recognition and alternative splicing. Additionally, she developed a technology (CRaft-ID) utilizing microraft arrays with high-throughput imaging to perform a CRISPR-screen for regulators of cytoplasmic protein-RNA assemblies in cells. As a graduate student, Emily was trained in both wet and dry lab techniques to develop a hybrid skill set between bioinformatics and bench work in the lab. In the Tothova lab, she is interested in studying the cross-talk between RNA splicing and cohesin function in various cell line and animal models of MDS and AML. Outside the lab, Emily loves to stay active with soccer (pre-pandemic times), rock climbing, cycling, and skiing.
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August 2020 - Farewell to FlorenceWe bid farewell to Florence Verbeek who has completed her masters thesis and is returning back to the Netherlands to complete her combined medical school/master's degree program at the University of Amsterdam. Congratulations and good luck, Florence!
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July 2020 - We are excited to present our work in the Connect : Science seminar seriesWe were honored to present our work at the Connect : Science seminar series organized by the Dana-Farber/Harvard Cancer Center and the Leukemia and Lymphoma Society. Click below to watch.
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June 2020 - Farewell to BeccaWe wish all the best to Becca Gorelov who is leaving the lab after two wonderful years to start her PhD in the Biological and Biomedical Sciences Program at Harvard Medical School this summer. We celebrated her time and many important scientific contributions in the lab with a socially distanced picnic. We are very sad to see her go but thrilled that she will be staying in Boston!
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June 2020 - Tothova Lab welcomes Dylan MillsonWe are very happy to welcome Dylan Millson who is joining our team as a new research associate. Dylan grew up in North Carolina and graduated from Williams College in 2020 with degrees in chemistry and biology. He was a four-year member of Williams wrestling team. Dylan completed his undergraduate thesis in the lab of Prof. Ben Thuronyi, where he developed a modular DNA toolkit to enable fluorescent proteins to form phase condensates in E. coli. In the Tothova lab, he aims to study genetic and epigenetic aberrations that contribute to myeloid malignancies. When he isn't in the lab, Dylan enjoys reading, lifting weights, and playing electric bass.
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March 2020 - Tothova Lab welcomes Will DoyleWe are very excited to welcome Will Doyle as a new research associate in the Tothova lab. Will grew up in Arlington, MA and graduated from Williams College in 2019 with a major in biology. For his undergraduate thesis in the lab of Prof. Lois Banta, he studied the connected roles of a plant defense hormone and the bacterial type VI secretion system in Agrobacterium tumefaciens infection. Will is joining the Tothova Lab to contribute to the understanding of epigenetic dysregulation in leukemia development. Outside of the lab, he enjoys playing jazz trombone, studying languages, and baking bread.
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March 2020 - Ben wins the Goldwater Scholarship!
Congratulations to our superstar undergraduate student Ben Maron who has been awarded a 2020 Goldwater Scholar award. Very well deserved!
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January 2020 - Tothova lab welcomes Florence VerbeekWe are thrilled to welcome Florence Verbeek as a visiting graduate student from the University of Amsterdam, Netherlands. Florence is currently pursuing a medical degree as well as a masters degree in Biomedical Sciences. She has previously studied drug resistance in gastrointestinal malignancies. Her work in the lab will focus on therapeutic targeting of cohesin-mutant MDS and AML. Outside of the lab, she is an avid CrossFitter, and enjoys reading and watching reruns of The Office.
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December 2019 - Secret SantaOur annual tradition. A few gifts remained to be found at the reveal party.
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December 2019 - ASH annual meetingMounica Vallurupalli presented the first oral presentation of the Tothova lab at the 2019 annual meeting of the American Society of Hematology in Orlando, FL. She discussed the development of new mouse models of cohesin-mutant myeloid disease and the preclinical studies with the PARP inhibitor talazoparib leading to a Phase 1b clinical trial of talazoparib in cohesin-mutant MDS/AML patients.
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November 2019 - Tothova lab welcomes Han LinWe are very excited to welcome Han Lin, PhD, a new postdoctoral fellow in the lab. Han Lin is joining our lab from the Cancer Science Institute of Singapore/National University of Singapore where she recently completed her PhD in Dr. Phil Koeffler’s lab. Her doctoral work was focused on understanding the function of ARID1A, a component of the SWI/SNF chromatin remodeling complex, in normal hematopoietic development. Welcome, Han Lin!
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September 2019 - Jimmy Fund WalkThe Tothova Lab and Friends participated in our second Jimmy Fund Walk on a beautiful first day of fall. This year, we walked the full marathon course and were still smiling at the finish line! Thank you to all of our supporters.
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September 2019 - Tothova lab welcomes Karin GolanWe are thrilled to welcome Karin Golan, PhD, a new postdoctoral fellow in the lab. Karin is joining our lab from the Weizmann Institute where she did her PhD with Tsvee Lapidot studying different aspects of basic hematopoietic stem cell biology, including the influence of light and darkness, mitochondrial transfer with bone marrow environment and the role of sphingosine 1-phosphate in HSC motility. Welcome, Karin!
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August 2019 - Farewell to our summer student Ben MaronWe are sad to see our fantastic summer student Ben Maron leave us to start his junior year at Williams College. He has had an incredibly productive summer in the lab and we are eager to welcome him back to the lab in a few months!
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July 2019 - Tothova Lab is awarded the Doris Duke Clinical Scientist Development AwardWe are very grateful to the Doris Duke Charitable Foundation for supporting our work on splicing in cohesin-mutant MDS/AML
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July 2019 - Tothova Lab welcomes Liana TellezToday, we welcomed Liana Tellez as the newest member of the lab. Liana is joining us from Northwestern University as a research associate in the Broad Genomics Scholar program.
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July 2019 - Tothova Lab turns 1!Today we celebrated the first year anniversary of our lab, celebrated friendships and collaborations, and welcomed a new addition to our team, Liana Tellez.
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June 2019 - Mounica's send off to the Brigham for her chief medical residency yearWe will miss Mounica as she embarks on her year as a chief medical resident at the Brigham and Women's Hospital.
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June 2019 - Tothova lab is awarded the Discovery Research grant from the Evans FoundationWe are very grateful to the EvansMDS initiative of the Evans Foundation to support our work on targeting DNA damage repair in cohesin-mutant MDS
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June 2019 - Tothova lab is awarded the inaugural RUNX1 Young Investigator AwardWe are very grateful for the support from the RUNX1 Research program and Alex's Lemonade Stand for our study of disease progression in familial platelet disorders to MDS and AML
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May 2019 - Tothova lab welcomes Ben MaronToday, we welcome Ben Maron to our lab. Ben is a rising junior at Williams College majoring in biology and mathematics, and a recipient of the Williams-Whitehead fellowship for the summer. He will be working on understanding the effect of cohesin complex mutations on nascent transcription.
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April 2019 - Zuzana Tothova receives the Tito Bastianello AwardWe are very grateful to the MDS Foundation for recognizing our work on mechanisms of cohesin mutations in myelodysplastic syndromes during the 15th International Symposium on Myelodysplastic syndromes in Copenhagen, Denmark.
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April 2019 - Celebrating our first PDX model! |
March 2019 - Ski tripOur winter getaway to Cranmore Mountain, NH.
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Birthday celebrations 2018-2019Aaaand... we are one year older!
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December 2018 - Tothova Lab Holiday Party
Our first annual holiday party marked by the first Christmas tree ornament.
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December 2018 - Secret Santa
The annual Secret Santa tradition dating back to the Gilliland lab era continues.
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December 2018 - ASH annual meeting
We attended the annual meeting of the American Society of Hematology in San Diego.
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October 2018 - B.A.A. Half Marathon
Congratulations to all the runners for conquering the Boston half marathon on this beautiful fall day!
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September 2018 - The Jimmy Fund Walk
The Tothova lab and friends team participated in the Jimmy Fund Walk celebrating its 30th anniversary on a beautiful first day of fall. We joined thousands of patients, families and care givers to walk 13.1 mile half marathon route from Wellesley to Boylston Street.
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August 2018 - Farewell to AnastasiaToday, we said goodbye to our fabulous summer student, Anastasia Tishena. She will be missed most for her mastery of the CellTiter-Glo assay as well as her wit in lab. Anastasia leaves us to start her junior year at Williams College. Click below to see some more photos of Anastasia's summer in the Tothova Lab.
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August 2018 - Sailing in the Charles RiverThe Tothova and Ebert lab spent this beautiful summer evening sailing in the Charles River. Click below to see some more photos!
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July 2018 - Farewell to KikiTo celebrate Kiki's last day in the Tothova and Ebert labs, we all set off to the Arboretum for a picnic! Kiki leaves the lab after two years. She is now off pursuing a Masters of Nutrition Science & Policy at Tufts University. We are all sad to see her go, but happy to know she'll be in Boston for the time being! Click below to see some photos from her farewell picnic.
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July 1, 2018 - Tothova Lab welcomes Anastasia TishenaToday, we also welcomed Anastasia to the Tothova Lab. Anastasia will be joining the lab for the next 10 weeks working on drug synergy experiments in various leukemia cell lines. Anastasia is joining us from Williams College, where she just finished up her sophomore year as a biology major and biochemistry concentrator.
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July 1, 2018 - Tothova Lab welcomes Rebecca GorelovToday, Rebecca joined the Tothova Lab as a research associate. Rebecca just graduated from Williams College as a biology major. She joins the lab to help develop different model systems to study leukemia.
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July 1, 2018 - Tothova Lab welcomes Mounica VallurupalliOn its opening day, the Tothova Lab welcomes our very first clinical fellow, Mounica Vallurupalli. She joins us from Dana Farber, where she is a clinical fellow in hematology-oncology. In the lab she will be studying the role of epigenetic alterations, including in the cohesin complex, in the development of leukemia as well as in mediating response and resistance to therapy.
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